Universo Eletrico (Eletric Universe)

    View Online     APPLICATION NOTE Capturing the whole organoid in a single shot         Dear Researcher, If you screen drug response in 3D organoid models, you know the trade-off well. Image each organoid in full 3D and a whole plate can take a very long time; flatten it to a single 2D plane and you lose the very morphology that made a 3D model worth using. We are excited to share an application note we recently published with InSphero that offers a way around this. Using the ZEISS LSM 990 with Lightfield 4D, we captured the entire volume of each organoid in a single snapshot — no serial z-stacking — and ran quantitative drug-response screening across a full 384-well plate.     A few results stood out. Colorectal tumor–stroma co-cultures trea...

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